Changes in Gray Matter Volume in Chronic Nonfluent Aphasia after Cortical Cerebral Infarction
10.3969/j.issn.1006-9771.2021.00.003
- VernacularTitle:脑皮质梗死慢性期非流利性失语症灰质体积的改变
- Author:
Yan-hong DAI
1
;
Jia-ying HUANG
2
;
Hai-long LUO
2
;
Rui-qing WANG
1
;
Ying-an HUANG
1
;
Zhuo-ming CHEN
1
;
Hong WANG
1
Author Information
1. Department of Rehabilitation Medicine, the First Affiliated Hospital of Ji'nan University, Guangzhou, Guangdong 510000, China
2. Department of Radiology, the First Affiliated Hospital of Ji'nan University, Guangzhou, Guangdong 510000, China
- Publication Type:Research Article
- Keywords:
cerebral infarction;
aphasia;
structural magnetic resonance imaging;
voxel-based morphological measurement;
gray matter volume
- From:
Chinese Journal of Rehabilitation Theory and Practice
2021;27(7):785-790
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes of gray matter volume in patients with chronic nonfluent aphasia after cortical cerebral infarction and the relationship between gray matter volume and language function. Methods:From June, 2016 to June, 2019, 19 patients with chronic nonfluent aphasia after cortical cerebral infarction from the First Affiliated Hospital of Ji'nan University and 28 healthy subjects (controls) were scanned with structural magnetic resonance imaging. The data were analyzed using voxel-based morphological measurement to measure the gray matter volumes of the brain regions, and the differences between patients and controls were compared. The correlation between volumes of brain regions with difference and scores of items of Aphasia Battery of Chinese (ABC) was analyzed. Results:The gray matter volumes increased in the brain regions of right inferior frontal gyrus triangle, right inferior frontal gyrus island cover, right angular gyrus, the right medial frontal gyrus, left insula, left medial frontal gyrus in the patients; while decreased in right globus pallidus. The volumes of left insular lobe correlated with the scores of repeating (r = 0.665, P = 0.001) and naming (r = 0.638, P = 0.003); and the volumes of right inferior frontal gyrus triangle correlated with the scores of hearing comprehension (r = 0.493, P = 0.031), repeating (r = 0.576, P = 0.009) and naming (r = 0.674, P = 0.001) in the patients. Conclusion:The cortex volumes of left insula and right inferior frontal gyrus triangle increase in patients with chronic nonfluent aphasia after cerebral infarction, which may play a role in the language dysfunction.
