Pathogenesis of drug-induced liver injury: Current understanding and future needs
10.3969/j.issn.1001-5256.2021.11.003
- VernacularTitle:药物性肝损伤的发生机制：当前认识和未来需求
- Author:
Yuecheng YU
1
;
Chengwei CHEN
2
Author Information
1. Department of Infectious Diseases and Center of Liver Diseases, General Hospital of Eastern Theater Command, Nanjing 210002, China
2. Liver Diseases Research Center, The 905 Hospital Affiliated to Navy Medical University, Shanghai 200235, China
- Publication Type:Discussions by experts
- Keywords:
Chemical and Drug-Induced Liver Injury;
Risk Factors;
Pathogenesis
- From:
Journal of Clinical Hepatology
2021;37(11):2515-2524
- CountryChina
- Language:Chinese
-
Abstract:
The risk factors for drug-induced liver injury (DILI) involve host factors (including general non-genetic factors and idiosyncratic genetic and immune factors), drug-related factors, and environmental factors. The pathogenesis of DILI can be classified as intrinsic (or direct) hepatotoxicity, idiosyncratic hepatotoxicity, and indirect hepatotoxicity, as well as tumorigenicity and carcinogenicity of some drugs to the liver. The pathogenesis of different types of hepatotoxicity not only has significant differences, but also has internal correlation at multiple links. The three-step model centered on mitochondrial permeability transition (MPT) and a two-stage model with liver cell regeneration and liver tissue repair capacity as the determinants of different outcomes display the mechanism progress of DILI from different perspectives. Clarification of the complex pathogenesis of DILI needs long-term collection of clinical cases and systematic studies, which is of great significance for the scientific prevention, diagnosis, and treatment of DILI.
