Role of regulatory T/T helper 17 cells in the pathogenesis of autoimmune hepatitis and related therapeutic targets
10.3969/j.issn.1001-5256.2021.10.042
- VernacularTitle:调节性T淋巴细胞/辅助性T淋巴细胞17在自身免疫性肝炎发生发展中的作用机制及其相关治疗靶点
- Author:
Wendi DONG
1
;
Hairong ZHANG
1
;
Rui LI
1
;
Yuyan ZHANG
1
;
Jie ZHU
1
Author Information
1. Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
- Publication Type:Reviews
- Keywords:
Hepatitis, Autoimmune;
T-Lymphocytes, Regulatory;
T-Lymphocytes, Helper-Inducers
- From:
Journal of Clinical Hepatology
2021;37(10):2456-2460
- CountryChina
- Language:Chinese
-
Abstract:
The etiology and pathogenesis of autoimmune hepatitis (AIH) remain unclear and are currently considered to be associated with genetic susceptibility and environmental factors. Regulatory T (Treg) cells play an immunosuppressive role by secreting IL-10 and TGFβ, while T helper 17 (Th17) cells mainly promote inflammatory response, suggesting that Treg cells, Th17 cells, and the dynamic balance between them may be involved in the development and progression of AIH; however, further studies are needed to explore related participation mechanisms. This article reviews the association between Treg/Th17 cells and AIH in recent years and elaborates on their mechanism of action and therapeutic targets.
