Application of metagenomic next-generation sequencing in sepsis in liver cirrhosis
10.3969/j.issn.1001-5256.2021.09.041
- VernacularTitle:宏基因组学测序技术在肝硬化脓毒症中的应用
- Author:
Xiaoge BEI
1
;
Jinjun CHEN
1
;
Beiling LI
1
Author Information
1. Liver Disease Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
- Publication Type:Reviews
- Keywords:
Liver Cirrhosis;
Sepsis;
Metagenomics;
Sequence Analysis
- From:
Journal of Clinical Hepatology
2021;37(9):2206-2209
- CountryChina
- Language:Chinese
-
Abstract:
Due to persistent systemic inflammation and immunosuppressive conditions, patients with liver cirrhosis are susceptible to bacterial infection, which may progress to sepsis without proper control. Early effective antibiotic therapy is the key to improving the prognosis of patients with sepsis. This article briefly describes the pathophysiological mechanism of sepsis in patients with liver cirrhosis and the current status of the diagnosis and treatment of sepsis, and it is pointed out that metagenomic next-generation sequencing can be used to guide effective antibacterial treatment of sepsis.
