Relationship between serum miR-199a-5p and miR-378a-3p levels and recurrence of infants with proliferative facial hemangioma after propranolol withdrawal
10.12016/j.issn.2096-1456.2022.02.004
- Author:
GUO Yan
1
;
ZHANG Kai
2
;
FAN Xuhui
3
;
LI Lifeng
4
Author Information
1. Department of Dental Emergency, Xi′an Jiaotong University Hospital of Stomatology
2. Department of Plastic Surgery, Hospital of Stomatology, Air Force Military Medical University
3. Department of Oral and Maxillofacial Surgery, Second Hospital of Hebei Medical University
4. Department of Traumatology and Plastic Surgery, Hospital of Stomatology, Xi′an Jiaotong University
- Publication Type:Journal Article
- Keywords:
micro ribonucleic acid;
miR-199a-5p;
miR-378a-3p;
propranolol;
infant;
hemangioma;
recurrence;
endothelial cell proliferation
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2022;30(2):97-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between serum miR-199a-5p and miR-378a-3p levels and the recurrence of infants with proliferative facial hemangioma relapsed after propranolol withdrawal in infants.
Methods:Ninety-three infants with proliferative facial hemangioma were selected, all of whom received propranolol treatment. The recurrence of the hemangioma after treatment was followed up, and the children were divided into a recurrence group (23 patients) and a nonrecurrence group (70 patients). Venous blood was collected before and after treatment, and the serum levels of miR-199a-5p and miR-378a-3p were detected by qRT-PCR, and the relationship between the serum levels of miR-199a-5p and miR-378a-3p and the recurrence of proliferative facial hemangioma relapsed after propranolol withdrawal in infants was analyzed.
Results : The serum expressions levels of miR-199a-5p and miR-378a-3p in non-relapsed group were increased after treatment compared with before treatment (P < 0.05), and there was no significant difference in the levels of miR-199a-5p and miR-378a-3p in the serum of the recurrence group after treatment compared with before treatment (P > 0.05). After treatment, the levels of miR-199a-5p and miR-378a-3p in the serum of the recurrence group were lower than those of the nonrecurrence group (P < 0.05). After treatment, the serum levels of miR-199a-5p and miR-378a-3p in patients with Ⅲ ~Ⅳ Norm grade hemangioma were higher than those in patients with Ⅰ~Ⅱ Norm grade hemangioma (P < 0.05). Logistic regression analysis showed that the low expression of miR-199a-5p, low expression of miR-378a-3p and tumor grade Ⅰ~Ⅱ after treatment were risk factors for the recurrence of proliferative facial hemangioma after propranolol withdrawal in infants (P < 0.05).
Conclusion: Low serum levels of miR-199a-5p and miR-378a-3p are associated with the recurrence of proliferative facial hemangioma after propranolol withdrawal in infants.
- Full text:血清miR-199a-5p miR-378a-3p水平与婴幼儿增殖期面部血管瘤普萘洛尔停药后复发的关系.pdf
