Solitary myeloma with massive extracellular crystalline structures: a case report.
10.3346/jkms.1991.6.2.165
- Author:
Yong Gu KIM
1
;
Ki Hwa YANG
;
Seok Jin GANG
;
Byoung Kee KIM
;
Sun Moo KIM
Author Information
1. Department of Clinical Pathology, Catholic University Medical College, Seoul, Korea.
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
Solitary myeloma;
Extracellular crystalline structures;
Immunoperoxidase staining;
Electron microscopy
- MeSH:
Bone Neoplasms/immunology/*ultrastructure;
Crystallization;
Extracellular Space/immunology;
Female;
Humans;
Immunoglobulin lambda-Chains/ultrastructure;
Microscopy, Electron;
Middle Aged;
Plasmacytoma/immunology/*ultrastructure
- From:Journal of Korean Medical Science
1991;6(2):165-171
- CountryRepublic of Korea
- Language:English
-
Abstract:
We describe a case of solitary myeloma showing cystic change filled with massive crystalline structures in a 54-year-old woman. A bone X-ray showed a solitary cystic osteolytic lesion in the right iliac bone. Serum and urine protein electrophoresis showed no demonstrable M-protein, and bone-marrow aspirates did not show any myeloma cells. Histologic examination of the tumor revealed aggregation of plasma cells with massive extracellular infiltration of the rhomboid-shaped crystalline structures. In immunoperoxidase staining, both these crystalline structures and the cytoplasms of the myeloma cells demonstrated a positive reaction for lambda light chain. By electron microscope, the large extracellular crystalline structures were observed, and we found unique rhomboid or rectangular-shaped crystalline structures in the cytoplasms of the myeloma cells.
