A New Stilbene Dimer and Other Chemical Constituents from Monanthotaxis littoralis with Their Antimicrobial Activities

Arnaud Joseph NGUETSE DONGMO; Steve Endeguele EKOM; Ean-de-Dieu TAMOKOU; Cyrille Ngoufack TAGOUSOP; Dominique HARAKAT; Laurence VOUTQUENNE-NAZABADIOKO; David NGNOKAM

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A New Stilbene Dimer and Other Chemical Constituents from Monanthotaxis littoralis with Their Antimicrobial Activities

Author: Arnaud Joseph NGUETSE DONGMO ^{1
,

2} ; Steve Endeguele EKOM ; Ean-de-Dieu TAMOKOU ; Cyrille Ngoufack TAGOUSOP ; Dominique HARAKAT ; Laurence VOUTQUENNE-NAZABADIOKO ; David NGNOKAM
Author Information

1. Research Unit of Applied and Environmental Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box
2. Dschang Cameroon
Publication Type:Original Article
From:Natural Product Sciences 2020;26(4):317-325
CountryRepublic of Korea
Language:English
Abstract: A new dimer stilbene [Monalittorin (1)] and ten known compounds [engeletin (2), aurantiamide acetate (3), lupeol (4), friedelin (5), quercetin (6), tiliroside (7), rutoside (8), astragalin (9), isoquercitrin (10) and quercimeritroside (11)] have been isolated from the leaves of Monanthotaxis littoralis (Annonaceae). The structures of these compounds were established by interpretation of their data, mainly, HR-TOFESIMS, 1-D NMR ( 1H and 13C) and 2-D NMR ( 1H-1H COSY, HSQC, HMBC and NOESY) and by comparison with the literature. The evaluation of their antimicrobial activities against three bacteria (Staphylococcus aureus ATCC 25923, Escherichia coli S2 (1) and Pseudomonas aeruginosa PA01) and three fungal strains (Candida albicans ATCC10231, Candida tropicalis PK233 and Cryptococcus neoformans H99) using broth micro dilution method, showed the largest antimicrobial activities of EtOAc fraction and compounds 1, 5, 6, 8 and 11 (MIC = 8 - 64 μg/ mL). In addition, EtOAc fraction presented synergistic effect with Vancomycin and fluconazole against the tested microorganisms.