Longitudinal Observation of Early-Onset Alzheimer’s Disease Dementia with Positive CSF Biomarkers/Negative Amyloid-β Positron-Emission Tomography
- Author:
Min Hye KIM
1
;
Joonho LEE
;
Hong Nam KIM
;
In Ja SHIN
;
Keun LEE
;
Yoon Seob KIM
;
Sun Min LEE
;
Sun Ah PARK
;
So Young MOON
Author Information
- Publication Type:증례
- From:Journal of the Korean Neurological Association 2021;39(3):214-218
- CountryRepublic of Korea
- Language:Korean
- Abstract: We report a 61-year-old woman with clinical course for Alzheimer’s disease (AD) dementia and discordant amyloid-β positron-emission tomography (PET) and cerebrospinal fluid biomarkers. Brain magnetic resonance imaging revealed remarkable atrophy in the hippocampus. However, repeated delayed 18F-flutemetamol brain amyloid PET images with 1 year-interval revealed no amyloid deposition, whereas her CSF revealed low Aβ42, high total tau and p-tau181. This discordant amyloid-β PET and CSF biomarkers in this early-onset AD dementia might be associated with her low resilience or mixed pathology.
