Role of urine osmolality as a predictor of the effectiveness of combined imipramine and desmopressin in the treatment of monosymptomatic nocturnal enuresis.
10.12701/yujm.2015.32.2.85
- Author:
Kwon Soo LEE
1
;
Jun Bo CHANG
;
Jae Yoon JANG
;
Young Hwii KO
;
Yong Hoon PARK
;
Phil Hyun SONG
Author Information
1. Department of Urology, College of Medicine, Yeungnam University, Daegu, Korea. sph04@hanmail.net
- Publication Type:Original Article
- Keywords:
Enuresis;
Urine;
Osmolality
- MeSH:
Deamino Arginine Vasopressin*;
Enuresis;
Humans;
Imipramine*;
Nocturnal Enuresis*;
Osmolar Concentration*
- From:Yeungnam University Journal of Medicine
2015;32(2):85-89
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We examined the usefulness of urine osmolality, as a predictive factor in the treatment of monosymptomatic nocturnal enuresis (NE) with combination therapy of imipramine and desmopressin. METHODS: From May 2014 to April 2015, 59 monosymptomatic NE patients participated in this study. Early morning urine osmolality was measured at 1 week and 1 day before combination therapy of imipramine and desmopressin, and at 1 week and 2 weeks after therapy. The response to combination therapy was evaluated at 3 months after treatment. The mean period of combination therapy was 6.4+/-4.2 weeks. Therapeutic response was classified as complete (0-1 wet night/week), partial (over 50% reduction of night) and non-responders (less than 50% reduction of night). RESULTS: The cumulative rate of the complete and partial responders was 76.3%. Among the 3 groups, the statistically lowest value of pre-treatment urine osmolality was observed in the complete responder group (p<0.001). Urine osmolality increased in all groups after treatment, however, statistically the greatest difference between pre and post-treatment urine osmolality was observed in the complete responder group (p=0.024). No serious side effects were observed. CONCLUSION: Early morning urine osmolality and change of urine osmolality between pre and post-treatment have predictive values in the response to combined imipramine and desmopressin for treatment of monosymptomatic NE.
