Chromosomal Deletion in 7q31.2-31.32 Involving Ca2âº-Dependent Activator Protein for Secretion Gene in a Patient with Cerebellar Ataxia: a Case Report
- Author:
Seungbeen HONG
1
;
Su Ji LEE
;
Sung Rae CHO
Author Information
- Publication Type:Case Report
- From:Brain & Neurorehabilitation 2020;13(1):e9-
- CountryRepublic of Korea
- Language:English
- Abstract: We present a 33-year-old male patient with cerebellar ataxia. He was first considered to have a psychiatric conversion disorder but finally found to have chromosomal deletion in 7q31.2-31.32 involving Ca2âº-dependent activator protein for secretion (CADPS) gene. When a targeted gene sequencing using next-generation sequencing panel and chromosomal microarray analysis were performed, an 8.6 Mb deletion within chromosome 7q31.2-31.32 was discovered. Deletion of CADPS gene in the 7q31.2-31.32 was suggested as the causative factor of cerebellar ataxia. Functional levels evaluated by Berg balance scale and modified Barthel index were improved via comprehensive rehabilitation including balance training and a dopamine agonist medication. To the best of our knowledge, this is the first report of chromosomal deletion in 7q31.2-31.32 including CADPS gene detected in patients with cerebellar ataxia.
