Long-Term Survival in Stage IV Esophageal Adenocarcinoma with Chemoradiation and Serial Endoscopic Cryoablation.
- Author:
Zachary SPIRITOS
1
;
Parit MEKAROONKAMOL
;
Bassel F EL-RAYES
;
Seth D FORCE
;
Steven A KEILIN
;
Qiang CAI
;
Field F WILLINGHAM
Author Information
- Publication Type:Case Report
- Keywords: Esophageal neoplasms; Cryosurgery; Adenocarcinoma
- MeSH: Adenocarcinoma*; Cryosurgery*; Cryotherapy; Drug Therapy; Esophageal Neoplasms; Freezing; Prognosis
- From:Clinical Endoscopy 2017;50(5):491-494
- CountryRepublic of Korea
- Language:English
- Abstract: Esophageal cancer has a poor overall prognosis and is frequently diagnosed at a late stage. Conventional treatment for metastatic esophageal cancer involves chemotherapy and radiation. Local disease control plays a significant role in improving survival. Endoscopic spray cryotherapy is a novel modality that involves freezing and thawing to produce local ablation of malignant tissue via ischemic mechanisms. Spray cryotherapy has been shown to be effective, particularly for early T-stage, superficial esophageal adenocarcinomas. We present the case of a 72-year-old-male with locally recurrent stage IV esophageal adenocarcinoma and long-term survival of 7 years to date, with concurrent chemoradiation and serial cryoablation. He remains asymptomatic and continues to undergo chemotherapy and sequential cryoablation. The findings highlight the long-term safety and efficacy of cryotherapy in combination with chemoradiation, and suggest that cryoablation may have an additive role in the treatment of advanced stage esophageal adenocarcinoma.
