Efficacy of Evolocumab in Patients with Hypercholesterolemia
10.7180/kmj.2020.35.2.125
- Author:
Xuan JIN
1
;
Moo Hyun KIM
;
Young-Rak CHO
;
Jong-Sung PARK
;
Kai SONG
;
Song Lin YUAN
Author Information
1. Department of Cardiology, Dong-A University College of Medicine, Busan, Korea
- Publication Type:Original Article
- From:Kosin Medical Journal
2020;35(2):125-132
- CountryRepublic of Korea
- Language:English
-
Abstract:
Objectives:The FOURIER trial reported that inhibition of PCSK9 with evolocumab on a background of statin therapy lowered low-density lipoprotein (LDL) cholesterol levels to a median of 30 mg per deciliter (0.78 mmol per liter) and reduced the risk of cardiovascular events. Here, we report data from a single center focusing on the effect of a PCSK9 inhibitor antibody on hyperlipidemia.
Methods:We enrolled 29 hypercholesterolemia patients who had LDL cholesterol levels ≥ 70 mg per deciliter or nonHDL cholesterol ≥ 100 mg per deciliter and were divided into two groups (placebo n = 14, evolocumab n = 15), and participated in a 72 - 96 week, randomized, double-blind, placebo-controlled trial with statin therapy. Patients were randomly assigned to receive evolocumab (140 mg every 2 weeks or 420 mg monthly) or matched placebo via subcutaneous injection. Lipid changes during follow-up were analyzed.
Results:The median LDL cholesterol level at baseline was 88 mg per deciliter, and the average LDL cholesterol level was 101.8 ± 20.0 mg per deciliter. At 4 weeks, the median LDL cholesterol level was 39 mg per deciliter, and the average LDL cholesterol level was 34.8 ± 51.8 mg per deciliter. Compared to placebo group, the LDL cholesterol levels were significantly reduced after treatment (P < 0.001), as well as total cholesterol, ApoB, and ApoB / ApoA1 levels. During follow-up, no discomfort was reported at local injection sites, and no cases of abnormal liver function were observed.
Conclusions:Evolocumab significantly reduced LDL cholesterol levels and was well tolerated.
