Microvasculature and Nerve Fiber Layer-Ganglion Cell Inner Plexiform Layer Thickness in Type 2 Diabetes
10.3341/jkos.2021.62.6.769
- Author:
Jin-Seok SEO
1
;
Yong-Wun CHO
;
Seong-Wook SEO
;
Seong-Jae KIM
;
In Young CHUNG
;
Woong-Sun YOO
Author Information
1. Department of Ophthalmology, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea
- Publication Type:Original Article
- From:Journal of the Korean Ophthalmological Society
2021;62(6):769-776
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Purpose:To investigate thickness of the nerve fiber layer-ganglion cell inner plexiform layer (NFL-GCIPL) complex and vessel density of the superficial and deep retinal vessels and choriocapillaris using swept source optical coherence tomography (SS-OCT) and angiography (OCTA) in type 2 diabetic patients without diabetic retinopathy (DR).
Methods:Sixty-four eyes of type 2 diabetic patients without DR were included. A control group of 54 eyes without diabetes was also recruited. All patients underwent multimodal imaging evaluation using SS-OCT and OCTA.
Results:Vessel density of the superficial and deep retinal vessels was not different between the study and control groups. A significant decrease in NFL-GCIPL complex thickness was observed in the study group compared to the control group. NFL-GCIPL thickness of the macula decreased with increased duration of diabetes.
Conclusions:These results suggest that neurodegeneration might be an early change in the development of DR.
