Effect of Human or Mouse IL-7 on the Homeostasis of Porcine T Lymphocytes
- Author:
Ji Hwa HONG
1
;
Sang Hoon KIM
;
Hyun Gyung KIM
;
Jun Ho JANG
;
Ryeo Gang SON
;
Seung Pil PACK
;
Young-Ho PARK
;
Philyong KANG
;
Kang-Jin JEONG
;
Ji-Su KIM
;
Hanbyeul CHOI
;
Sun-Uk KIM
;
Yong Woo JUNG
Author Information
- Publication Type:Original Article
- From:Immune Network 2021;21(3):e24-
- CountryRepublic of Korea
- Language:English
- Abstract: Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid to the development of artificial blood using other animals. Although mini-pigs are candidate animals, contamination of mini-pig T cells in artificial blood may cause a major safety concern. Therefore, it is important to analyze the cross-reactivity of IL-7, the major survival factor for T lymphocytes, between human, mouse, and mini-pig. Thus, we compared the protein sequences of IL-7 and found that porcine IL-7 was evolutionarily different from human IL-7. We also observed that when porcine T cells were cultured with either human or mouse IL-7, these cells did not increase the survival or proliferation compared to negative controls. These results suggest that porcine T cells do not recognize human or mouse IL-7 as their survival factor.
