Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy.

Author: Xiaojun SONG ¹ ; Jianming LV ² ; Zhiqin CAO ² ; Huiyun HUANG ² ; Guodong CHEN ² ; Takayoshi AWAKAWA ³ ; Dan HU ² ; Hao GAO ¹ ; Ikuro ABE ³ ; Xinsheng YAO ¹
Author Information

1. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
2. Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China.
3. Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo 113-0033, Japan.
Publication Type:Journal Article
Keywords: Combinational biosynthesis; Fungi; Fusidane-type antibiotics; Tailoring enzymes; Triterpenoids
From: Acta Pharmaceutica Sinica B 2021;11(6):1676-1685
CountryChina
Language:English
Abstract: Fusidane-type antibiotics, represented by helvolic acid, fusidic acid and cephalosporin P