Biotransformation of α-asarone by Alternaria longipes CGMCC 3.2875.
10.1016/S1875-5364(21)60088-2
- Author:
Jian ZOU
1
;
Shuai ZHANG
2
;
Huan ZHAO
3
;
Yong-Heng WANG
4
;
Zheng-Qun ZHOU
4
;
Guo-Dong CHEN
4
;
Dan HU
4
;
Ning LI
2
;
Xin-Sheng YAO
5
;
Hao GAO
6
Author Information
1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China.
2. College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
3. College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China.
4. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China.
5. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
6. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China; College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: tghao@jnu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Alternaria longipes CGMCC 3.2875;
Anti-Aβ(42) aggregation activity;
Biotransformation;
α-Asarone
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(9):700-705
- CountryChina
- Language:English
-
Abstract:
Biotransformation of α-asarone by Alternaria longipes CGMCC 3.2875 yielded two pairs of new neolignans, (+) (7S, 8S, 7'S, 8'R) iso-magnosalicin (1a)/(-) (7R, 8R, 7'R, 8'S) iso-magnosalicin (1b) and (+) (7R, 8R, 7'S, 8'R) magnosalicin (2a)/(-) (7S, 8S, 7'R, 8'S) magnosalicin (2b), and four known metabolites, (±) acoraminol A (3), (±) acoraminol B (4), asaraldehyde (5), and 2, 4, 5-trimethoxybenzoic acid (6). Their structures, including absolute configurations, were determined by extensive analysis of NMR spectra, X-ray crystallography, and quantum chemical ECD calculations. The cytotoxic activity and Aβ
