Higher-order assemblies in immune signaling: supramolecular complexes and phase separation.
10.1007/s13238-021-00839-6
- Author:
Shiyu XIA
1
;
Zhenhang CHEN
2
;
Chen SHEN
1
;
Tian-Min FU
3
Author Information
1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
2. Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, 43210, USA.
3. Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH, 43210, USA. fu.978@osu.edu.
- Publication Type:Review
- Keywords:
BCR;
RLR;
TCR;
TLR;
TNFR;
cGAS;
death domain;
higher-order assembly, phase separation, signalosome;
immune signaling;
inflammasome
- From:
Protein & Cell
2021;12(9):680-694
- CountryChina
- Language:English
-
Abstract:
Signaling pathways in innate and adaptive immunity play vital roles in pathogen recognition and the functions of immune cells. Higher-order assemblies have recently emerged as a central principle that governs immune signaling and, by extension, cellular communication in general. There are mainly two types of higher-order assemblies: 1) ordered, solid-like large supramolecular complexes formed by stable and rigid protein-protein interactions, and 2) liquid-like phase-separated condensates formed by weaker and more dynamic intermolecular interactions. This review covers key examples of both types of higher-order assemblies in major immune pathways. By placing emphasis on the molecular structures of the examples provided, we discuss how their structural organization enables elegant mechanisms of signaling regulation.
