Shexiang Tongxin Dropping Pill () Reduces Coronary Microembolization in Rats via Regulation of Mitochondrial Permeability Transition Pore Opening and AKT-GSK3β Phosphorylation.
10.1007/s11655-019-3176-6
- Author:
Yu DING
1
;
Hou-Yong ZHU
2
;
Li-Zong ZHANG
3
;
Bei-Bei GAO
4
;
Liang ZHOU
4
;
Jin-Yu HUANG
5
Author Information
1. Central Laboratory, Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
2. Department of Cardiology, Hangzhou Chinese Medical Hospital, Hangzhou, 310007, China.
3. Experimental Animal Research Center, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
4. Department of Cardiology, Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China.
5. Department of Cardiology, Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. hjyu41@sohu.com.
- Publication Type:Journal Article
- Keywords:
AKT;
Chinese medicine;
GSK3β;
Shexiang Tongxin Dropping Pill;
coronary microembolization;
mitochondrial permeability transition pore
- From:
Chinese journal of integrative medicine
2021;27(7):527-533
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To investigate the protective effects of Shexiang Tongxin Dropping Pill (, STDP) following sodium laurate-induced coronary microembolization (CME) in rats.
METHODS:Forty rats were divided into 4 groups: the control (sham) group, CME group, low-dose STDP pretreatment group (20 mg·kg
RESULTS:The rats in the CME group showed a significant increase in the fibrinogen-like protein 2 expression level and mitochondrial dysfunction and a decrease in the expression level of antioxidant biomarkers (superoxide dismutase and catalase, P<0.01 for all). In contrast, the rats in the low- and high-dose STDP pretreatment groups showed a significant decrease in coronary microthrombi (P<0.05); moreover, STDP restored the antioxidant-related protein activities and mitochondrial function, inhibited mPTP opening, decreased AKT-Ser473 phosphorylation, and increased GSK3β-Ser9 phosphorylation (P<0.05 or P<0.01).
CONCLUSION:STDP may be useful for treatment of CME, possibly via regulation of mPTP opening and AKT/GSK3β phosphorylation.
