Advances of phage receptor binding proteins.

Jiahui SUN; Peiling GENG; Xiaofu WAN; Zhiming YUAN; Hairong XIONG; Xiaomin HU

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Advances of phage receptor binding proteins.

Author: Jiahui SUN ¹ ; Peiling GENG ² ; Xiaofu WAN ¹ ; Zhiming YUAN ¹ ; Hairong XIONG ² ; Xiaomin HU ²
Author Information

1. Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, Hubei, China.
2. College of Life Science, South-Central University for Nationalities, Wuhan 430074, Hubei, China.
Publication Type:Review
Keywords: adsorption; phage; phage escape mechanism; phage-host interaction; receptor binding proteins (RBPs)
MeSH: Bacteria; Bacteriophage Receptors; Bacteriophages/genetics*; Carrier Proteins; Protein Binding
From: Chinese Journal of Biotechnology 2021;37(8):2614-2622
CountryChina
Language:Chinese
Abstract: Bacteriophages bind to the bacteria receptor through the receptor binding proteins (RBPs), a process that requires the involvement of complex atomic structures and conformational changes. In response to bacteriophage infection, bacteria have developed a variety of resistance mechanisms, while bacteriophages have also evolved multiple antagonistic mechanisms to escape host resistance. The exploration of the "adsorption-anti adsorption-escape process" between bacteriophages and bacteria helps us better understand the co-evolution process of bacteriophages and bacteria, which is important for the development of phage therapeutic technologies and phage-based biotechnologies. This review summarizes the bacteriophage adsorption related proteins, how bacteriophages escape host resistance based on the RBP alternations, and the recent progress of RBP-related biotechnologies.