Stem cell therapy for chronic obstructive pulmonary disease.
10.1097/CM9.0000000000001596
- VernacularTitle:Stem cell therapy for chronic obstructive pulmonary disease
- Author:
Yun-Tian CHEN
1
;
Kang MIAO
2
;
Linfu ZHOU
3
;
Wei-Ning XIONG
1
Author Information
1. Department of Pulmonary and Critical Care Medicine, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
2. Department of Pulmonary and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Key Cite of National Clinical Research Center for Respiratory Disease, Wuhan Clinical Medical Research Center for Chronic Airway Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
3. Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
- Publication Type:Review
- MeSH:
Humans;
Lung;
Mesenchymal Stem Cells;
Pulmonary Disease, Chronic Obstructive/therapy*;
Quality of Life;
Stem Cell Transplantation
- From:
Chinese Medical Journal
2021;134(13):1535-1545
- CountryChina
- Language:English
-
Abstract:
Chronic obstructive pulmonary disease (COPD), characterized by persistent and not fully reversible airflow restrictions, is currently one of the most widespread chronic lung diseases in the world. The most common symptoms of COPD are cough, expectoration, and exertional dyspnea. Although various strategies have been developed during the last few decades, current medical treatment for COPD only focuses on the relief of symptoms, and the reversal of lung function deterioration and improvement in patient's quality of life are very limited. Consequently, development of novel effective therapeutic strategies for COPD is urgently needed. Stem cells were known to differentiate into a variety of cell types and used to regenerate lung parenchyma and airway structures. Stem cell therapy is a promising therapeutic strategy that has the potential to restore the lung function and improve the quality of life in patients with COPD. This review summarizes the current state of knowledge regarding the clinical research on the treatment of COPD with mesenchymal stem cells (MSCs) and aims to update the understanding of the role of MSCs in COPD treatment, which may be helpful for developing effective therapeutic strategies in clinical settings.
