A novel dimeric diterpenoid alkaloid from the Tibetan medicinal plant Aconitum tanguticum (Maxim.) Stapf
10.16438/j.0513-4870.2020-1912
- VernacularTitle:藏药甘青乌头中1个新的双二萜生物碱
- Author:
Li-hua YANG
1
;
Yue WANG
2
;
Xiao-qian LIU
3
;
Yao-hua LIANG
3
;
Chun LI
3
;
Zhi-min WANG
3
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; Hunan University of Science and Engineering, Yongzhou 425199, China
2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; Guangdong Pharmaceutical University, Guangzhou 510006, China
3. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
- Publication Type:Research Article
- Keywords:
italic>Aconitum tanguticum;
iterpenoid alkaloid;
structural elucidation;
antiviral activity
- From:
Acta Pharmaceutica Sinica
2021;56(5):1429-1433
- CountryChina
- Language:Chinese
-
Abstract:
Two dimeric diterpenoid alkaloids were isolated from the whole plant of Aconitum tanguticum (Maxim.) Stapf and their structures were elucidated by extensive analysis of 1D, 2D-NMR and HR-MS data. One is a new compound and named tanguticurine A (1), and the other is the known compound anthoroidine B (2); both were isolated from this plant for the first time. The antiviral activity of compounds 1 and 2 against HCV and EV71 were also evaluated. It was found that compound 1 had a good inhibitory effect on HCV and EV71 with EC50 values of 15.5 and 9.7 μmol·L-1, respectively, and showed low cytotoxicity. Therefore, compound 1 is a good antiviral lead compound and deserves further study.
