Advances in dendritic cell-based vaccine delivery
10.16438/j.0513-4870.2021-0452
- VernacularTitle:基于树突状细胞的疫苗递送研究进展
- Author:
Yi-chi SHEN
1
;
Xue-lian FAN
1
;
Fei WANG
1
;
Gang CHEN
2
Author Information
1. Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
2. Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou 225009, China
- Publication Type:Research Article
- Keywords:
endritic cell;
antigen;
vaccine;
adaptive immunity;
nanoparticle
- From:
Acta Pharmaceutica Sinica
2021;56(9):2485-2494
- CountryChina
- Language:Chinese
-
Abstract:
Dendritic cells (DCs) are the most powerful and professional antigen-presenting cells (APCs) known at present. They play vital roles in the initiation and regulation of immune responses in body. Therefore, DC-based vaccine delivery system has gradually become a hotspot of basic scientific research and clinical treatment. DCs can be loaded with whole-cell antigens, nucleic acids, peptides, proteins (such as neoantigens) and nanoparticles to induce specific cellular immune responses and humoral immune responses after antigen processing, presentation and targeting delivery in vivo for the prevention and treatment of various diseases including cancers and microorganism infections. Vaccine-based on this technique is called dendritic cell (DC) vaccines. Great process in DC vaccines has been achieved in recent years. Therefore, we reviewed the characteristics of DC, types of DC vaccines and their clinical research progress in this paper.
