Advances in the pathogenesis of depression based on purinergic system and purine metabolism
10.16438/j.0513-4870.2021-0379
- VernacularTitle:基于嘌呤能系统及嘌呤代谢的抑郁症发病机制研究进展
- Author:
Jia-jun CHEN
1
;
Xue-mei QIN
1
;
Guan-hua DU
2
;
Yu-zhi ZHOU
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China; The Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province, Taiyuan 030006, China
2. Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
purinergic;
purine metabolism;
epression;
mechanism;
adenosine;
inosine;
guanosine
- From:
Acta Pharmaceutica Sinica
2021;56(9):2464-2471
- CountryChina
- Language:Chinese
-
Abstract:
Depression was a complex and difficult to regulate disease, which was closely related to purinergic system and purine metabolism disorder. Although there had been studies to improve depression by regulating purinergic system, the mechanism of action was complex and needed to be sorted out. Recently, a large number of studies had found that the addition of exogenous purine metabolites adenosine, inosine and guanosine had a significant antidepressant effect, indicating that regulating the level of purine substances in purine metabolism could also improve depression, which was of great significance to the further study of the pathogenesis and treatment of depression. In view of this, this study reviewed the relationship between purinergic system or purine metabolism and depression, in order to provide a reference for the further study of the pathogenesis of depression.
