Advances of research on CAR-T cell immunotherapy for solid tumors
10.11665/j.issn.1000-5048.20210413
- VernacularTitle:CAR-T细胞免疫治疗实体瘤的研究进展
- Author:
Zheng YAO
1
;
Zihan LI
;
Liming GAO
;
Xing HU
;
Yan CHEN
;
Wenqi PAN
;
Qian LI
Author Information
1. 中国药科大学生命科学与技术学院
- Publication Type:Journal Article
- Keywords:
chimeric antigen receptor T cell;
solid tumor;
immune microenvironment;
immunotherapy;
advances
- From:
Journal of China Pharmaceutical University
2021;52(4):496-504
- CountryChina
- Language:Chinese
-
Abstract:
Adoptive cellular immunotherapy has been widely recognized in recent years due to its remarkable results, especially the success of CD19-specific chimeric antigen receptor (CAR) autologous T cell therapy for malignant hematoma. Previous studies have found the existence of tumor immune microenvironment, heterogeneous targets, and immunosuppressive receptors in solid tumors, which has led to the shortcomings of CAR-T treatment of solid tumors. This article proposes the methods to improve CAR-T cells to increase T cell infiltration, co-expression of cytokines and enzymes and modification of related receptors in order to enhance the anti-solid tumor activity of CAR-T, laying a theoretical foundation for the follow-up CAR-T cell treatment of solid tumors.
