Design and antitumor activity of immune checkpoint B7-H3 epitope vaccine

VernacularTitle:免疫检查点B7-H3表位疫苗的设计及其抗肿瘤活性
Author: Xuefei XIA ; Li ZHANG ; Jianhua LUO ; Wenbing YAO ; Xiangdong GAO ; Hong TIAN
Publication Type:Journal Article
Keywords: immune checkpoint; B7-H3; epitope vaccine; tumor immunity
From: Journal of China Pharmaceutical University 2021;52(4):472-479
CountryChina
Language:Chinese
Abstract: B7-H3 is an immune checkpoint molecule overexpressed on the surface of a variety of tumors, and is is an ideal target for tumor immunotherapy. In this study, nitrolated T cell epitope designed in the early stage of the laboratory was used to construct an epitope vaccine that can target immune checkpoint B7-H3. The vaccine can significantly inhibit tumor growth in the CT26 colon cancer model, and has a significant synergistic effect with the PD-L1 protein vaccine. B7-H3 vaccine can increase the proportion of CD4+ T cells in splenic T lymphocytes and the proportion of CD8+ T cells in tumor-infiltrating T lymphocytes, while reducing the proportion of suppressor Treg cells in tumor-infiltrating CD4+ T lymphocytes, which effectively improves tumor immunosuppressive microenvironment. Research results suggest that the B7-H3 epitope vaccine can be used as an effective tumor vaccine candidate molecule.