Short-term efficacy of CT-guided microwave ablation for solitary pulmonary nodules
- VernacularTitle:孤立性肺结节 CT 引导下微波消融术后近期疗效分析
- Author:
Fen WANG
1
;
Tongfu YU
1
;
Xin ZHAO
2
,
3
;
Wei ZHANG
1
;
Hai XU
1
;
Yan ZHONG
1
;
Teng ZHANG
1
;
Xisheng LIU
1
Author Information
1. Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R.China
2. Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R.China;
3. Department of Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, P.R.China
- Publication Type:Journal Article
- Keywords:
Pulmonary nodules;
computed tomography;
microwave ablation;
short-term efficacy
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2021;28(08):928-934
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical feasibility and safety of CT-guided percutaneous microwave ablation for peripheral solitary pulmonary nodules. Methods The imaging and clinical data of 33 patients with pulmonary nodule less than 3 cm in diameter treated by CT-guided microwave ablation treatment (PMAT) in our hospital from July 2018 to December 2019 were retrospectively analyzed. There were 21 males and 12 females aged 38-90 (67.6±13.4) years. Among them, 26 patients were confirmed with lung cancer by biopsy and 7 patients were clinically considered as partial malignant lesions. The average diameter of 33 nodules was 0.6-3.0 (1.8±0.6) cm. The 3- and 6-month follow-up CT was performed to evaluate the therapy method by comparing the diameter and enhancement degree of lesions with 1-month CT manifestation. Short-term treatment analysis including complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD) was calculated according to the WHO modified response evaluation criteria in solid tumor (mRECIST) for short-term efficacy evaluation. Eventually the result of response rate (RR) was calculated. Progression-free survival was obtained by Kaplan–Meier analysis. Results CT-guided percutaneous microwave ablation was successfully conducted in all patients. Three patients suffered slight pneumothorax. There were 18 (54.5%) patients who achieved CR, 9 (27.3%) patients PR, 4 (12.1%) patients SD and 2 (6.1%) patients PD. The short-term follow-up effective rate was 81.8%. Logistic analysis demonstrated that primary and metastatic pulmonary nodules had no difference in progression-free time (log-rank P=0.624). Conclusion PMAT is of high success rate for the treatment of solitary pulmonary nodules without severe complications, which can be used as an effective alternative treatment for nonsurgical candidates.
