Study on the mechanism of IL-35 in autoimmune diseases
10.3760/cma.j.cn112309-20200606-00296
- VernacularTitle:IL-35在自身免疫性疾病中的机制研究
- Author:
Xu LIU
;
Siyu GONG
;
Zhikang TIAN
;
Junfeng ZHANG
- From:
Chinese Journal of Microbiology and Immunology
2021;41(5):411-416
- CountryChina
- Language:Chinese
-
Abstract:
As an anti-inflammatory factor, Interleukin 35 (IL-35) is composed of p35 subunit and EBI3 subunit. IL-35 plays an important role in many diseases, but many mechanisms are not clear. In recent years, it has been found that IL-35 plays an important immunomodulatory role in autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, idiopathic inflammatory myopathy, systemic lupus erythematosus, multiple sclerosis, type I diabetes, pemphigus and primary biliary cirrhosis, etc. This review summarizes the research progress of the mechanism of IL-35 in the above autoimmune diseases.
