Research advances in glucocorticoid-induced growth retardation

VernacularTitle:糖皮质激素所致生长障碍研究新进展
Author: Mingyue YIN ; Yuan XIAO
From: Chinese Journal of Endocrinology and Metabolism 2021;37(1):64-68
CountryChina
Language:Chinese
Abstract: Glucocorticoid is an important treatment for many pediatric diseases and it often leads to osteoporosis, osteonecrosis of the femoral head, and growth retardation. Among them, glucocorticoid-induced growth retardation has been a particular focus in the treatment of children patients, which leads to a decrease in final height. The mechanism of glucocorticoid-induced growth retardation is complex, and there is no safe and effective treatment.This article summarized the mechanisms underlying glucocorticoid-inhibited longitudinal bone growth and reviewed the potential therapeutic targets discovered in recent years.