Association of clinical features with sex hormone levels in 63 azoospermic patients with microdeletion of azoospermia factor C region
10.3760/cma.j.cn311282-20200114-00019
- VernacularTitle:63例成人无精子症AZFc缺失患者的临床特点及其与性激素水平相关性分析
- Author:
Zhouhui PAN
;
Xiuli ZHOU
;
Huijie LU
- From:
Chinese Journal of Endocrinology and Metabolism
2021;37(1):52-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical features of 63 azoospermic patients with microdeletion of azoospermia factor C region(AZFc) and their relationship with sex hormones.Methods:The clinical data of 63 azoospermic patients with AZFc microdeletion were retrospectively analyzed, including age, height, body weight, body mass index(BMI), testicular volume, and sex hormones.Results:Compared with normozoospermic men, height, body weight, and testicular volume revealed statistical differences in azoospermic patients with AZFc microdeletion( P<0.05). There were significant differences in FSH, LH, testosterone(T), and prolactin levels between two groups( P<0.05). BMI was negatively associated with FSH level( r=-0.251, P=0.04)and positively associated with estradiol(E 2)level( r=0.327, P=0.009). Age had a negative association with T level( r=-0.256, P=0.04). Testicular volume revealed a negative association with FSH level( r=-0.289, P=0.02). There were no association of height with T, E 2, FSH, and LH levels( P>0.05). Conclusion:It is more likely that azoospermic patients with AZFc microdeletion present overweight and earlier decreased androgen level. The adjustment of lifestyle and testosterone supplementation might be beneficial to the long-term quality of life in these patients.
