Application of T cell nuclear imaging strategy in chimeric antigen receptor T-cell immunotherapy

VernacularTitle:T细胞核医学分子成像策略在CAR-T免疫治疗中的应用
Author: Shuailiang WANG ; Hua ZHU ; Zhi YANG
From: Chinese Journal of Nuclear Medicine and Molecular Imaging 2021;41(3):175-179
CountryChina
Language:Chinese
Abstract: Chimeric antigen receptor T-cell (CAR-T) therapy is an emerging cancer immunotherapy strategy in recent years. CAR-T therapy has shown significant efficacy in the treatment of relapsed or refractory diffuse large B cell lymphoma and refractory pediatric acute lymphoblastic leukemia. However, restricted by the complexity of solid tumor microenvironment, the application of CAR-T therapy in solid tumors is still underway. Molecular imaging can trace the in vivo status of T cells in real time and in depth, which is of great significance to investigate the biological behavior of CAR-T cells in vivo and to evaluate their activation status. Meanwhile, molecular imaging strategy can also act as an early predictor of CAR-T treatment efficacy and related side effects, which can provide effective information for clinical intervention and play an important role in guiding the development of CAR-T therapy.