Recent progress and prospect for the relationship between autophagy and bronchopulmonary dysplasia

VernacularTitle:自噬与支气管肺发育不良关系的研究进展与展望
Author: Boshi YU ; Wenjuan CHEN ; Xiaohui CHEN ; Xingyun WANG
From: Chinese Journal of Applied Clinical Pediatrics 2021;36(9):711-714
CountryChina
Language:Chinese
Abstract: Bronchopulmonary dysplasia (BPD) is a commonly seen chronic lung disease in preterm infants.Although its etiology and pathophysiology have not been fully elucidated, it was thought to cause bronchoalveolar arrest.Autophagy is a certain programmed cell death process, which can achieve the renewal of organelles and metabolic needs.It is reported that autophagy is involved in all stages of lung development during the fetal period.The imbalance of autophagy plays an important role in the process of BPD.Furthermore, the appropriate regulation of autophagy could effectively improve lung injury.Now, the recent advancements of the role of autophagy in BPD is summarized in this review.