Effect of the antimicrobial photodynamic therapy in the treatment of periodontitis in type 2 diabetes mellitus: a systematic review and meta-analysis
10.12016/j.issn.2096-1456.2021.11.005
- Author:
XU Tengfei
1
;
CHEN Bin
1
;
AO Huizhi
1
;
SUN Weibin
1
;
WU WenLei
2
Author Information
1. Department of Periodontal, Nanjing Stomatological Hospital, Medical School of Nanjing University
2. Department of Senior Expert Diagnosis and Treatment, Nanjing Stomatological Hospital, Medical School of Nanjing University
- Publication Type:Journal Article
- Keywords:
antibacterial photodynamic therapy;
2 diabetes mellitus;
periodontitis;
subgingival scaling;
root planning;
periodontal therapy;
meta-analysis;
randomized controlled trail;
blood sugar control
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2021;29(11):752-760
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This systematic review and meta-analysis was undertaken to evaluate the efficacy of antibacterial photodynamic therapy (aPDT) in the treatment of periodontitis in type-2 diabetes mellitus (T2DM) patients and to provide better treatment for patients with T2DM complicated with periodontitis.
Methods:The PubMed, Cochrane, Embase, Web of Science, CNKI, CBM, and Wanfang databases were searched for relevant randomized controlled trials (RCTs). RevMan 5.3 was applied for the meta-analysis, and a systematic evaluation was conducted.
Results:A total of 8 RCTs were included. The results showed that compared to simple subgingival scaling and root planing (SRP), aPDT assisted SRP had a better effect on improving the probing depth (PD) at 3 months after treatment, The difference was statistically significant [WMD=-0.32,95%CI（-0.45, -0.2）, P < 0.05], but 6 months after treatment, there was no significant difference in the two groups [ WMD=-0.15,95%CI（-0.40, 0.10）,P=0.23]. During the 6-month follow-up period, there were no significant differences in the clinical attachment level (CAL), bleeding on probing (BOP) or hemoglobin A1c (HbA1c) between the two groups (P> 0.05).
Conclusion:aPDT-assisted periodontal nonsurgical treatment in T2DM patients can improve PD in the short term but has no significant effect on the improvement of CAL, BOP and HbA1c.
- Full text:抗菌光动力疗法对2型糖尿病牙周炎患者牙周治疗效果和血糖控制影响的系统评价与Meta分析.pdf
