Research and Development Status Quo of Respiratory Inhalation Preparations ：A Systematic Review
- VernacularTitle:呼吸系统吸入制剂研发现状的系统评价
- Author:
Zhe CHEN
1
;
Wenyan LI
2
;
Xiaofeng NI
3
;
Xiangcheng PAN
2
;
Lingli ZHANG
4
Author Information
1. Dept. of Pharmacy，West China Second University Hospital，Sichuan University，Chengdu 610041，China;Evidence- based Pharmacy Center，West China Second University Hospital，Sichuan University，Chengdu 610041，China;Key Laboratory of Birth Defects and Related Diseases of Women and Children，Ministry of Education，Chengdu 610041，China
2. Dept. of Pharmacy，West China Second University Hospital，Sichuan University，Chengdu 610041，China;Evidence- based Pharmacy Center，West China Second University Hospital，Sichuan University，Chengdu 610041，China;Key Laboratory of Birth Defects and Related Diseases of Women and Children，Ministry of Education，Chengdu 610041，China;West China School of Pharmacy，Sichuan University，Chengdu 610041，China
3. Dept. of Pharmacy，West China Second University Hospital，Sichuan University，Chengdu 610041，China;Evidence- based Pharmacy Center，West China Second University Hospital，Sichuan University，Chengdu 610041，China;Key Laboratory of Birth Defects and Related Diseases of Women and Children，Ministry of Education，Chengdu 610041，China;West China Clinical Medical College，Sichuan University，Chengdu 610041，China
4. Dept. of Pharmacy，West China Second University Hospital，Sichuan University，Chengdu 610041，China;Evidence- based Pharmacy Center，West China Second University Hospital，Sichuan University，Chengdu 610041，China
- Publication Type:Journal Article
- Keywords:
Respiratory system;
Inhalation preparations;
Research and development of medicine;
Status quo;
Systematic
- From:
China Pharmacy
2021;32(14):1671-1677
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To systematically evaluate the research and development status quo of respiratory inhalation preparations. METHODS ：Related literatures or data about R&D status quo of domestic and foreign respiratory inhalation preparations were retrieved from 5 databases（PubMed，Embase，CNKI，Wanfang database and VIP ），4 clinical trial registration platforms，15 national/regional drug administration platforms and yaozhi.com . The status quo of related studies was analyzed by descriptive analysis. RESULTS & CONCLUSIONS ：A total of 27 second literatures were included. The information of respiratory inhalation preparations approved by European Union ，the United States ，Canada，Japan and China was collected ，and the information of related drugs under registration and approval in China was also collected. The market situation of respiratory inhalation preparations was analyzed from the perspective of dosage form ：powder aerosols accounted for 46％，aerosols account ed for 32％，and atomized inhalation solutions accounted for 22％ in the global consumption sum of each dosage form. From the perspective of market share ，companies such as AstraZeneca in the UK ，Boehringer Ingelheim in Germany and GlaxoSmithKline in the UK had a total market share of about 70％. At present ，there were 39 kinds of respiratory inhalation preparations on the market in European Union ，121 kinds in the United States ，111 kinds in Canada ，37 kinds in Japan ，69 kinds of domestic inhalation preparations and 80 kinds of imported inhalation preparations in China. Respiratory inhalation preparations were undergoing clinical trials with 511 cases abroad and 69 cases in China. The barriers to the imitation of respiratory inhalation preparations mainly included research and development ，clinical trial ，approval and production barriers. At present ，the support is provided for 0035） domestic drug innovation and localization of medical devices in China through a series of policies ，which is helpful to promote the localization research and development of inha led preparations. Future research and development can pay more cn attention to combination ，indication，dosage and device of inhalation preparation.
