Uptake and trafficking of different sized PLGA nanoparticles by dendritic cells in imiquimod-induced psoriasis-like mice model.
10.1016/j.apsb.2020.11.008
- Author:
Zibei LIN
1
;
Long XI
1
;
Shaokui CHEN
1
;
Jinsong TAO
1
;
Yan WANG
2
;
Xin CHEN
1
;
Ping LI
2
;
Zhenping WANG
3
;
Ying ZHENG
1
Author Information
1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China.
2. Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University, Beijing 100050, China.
3. Department of Dermatology, School of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.
- Publication Type:Journal Article
- Keywords:
APCs, antigen-presenting cells;
Biofate;
CLSM, confocal laser scanning microscope;
DCs, dendritic cells;
DMF, dimethylformamide;
Dendritic cells;
DiI, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate;
DiO, 3,3′-dioctadecyloxacarbocyanine perchlorate;
Fluorescence;
Fluorescence resonance energy transfer;
Lymphoid organs;
MLN, mesenteric lymph nodes;
NPs, nanoparticles;
PDI, polydispersity index;
PFA, paraformaldehyde;
PLGA nanoparticles;
Psoriasis;
SDLN, skin-draining lymph nodes;
Uptake and trafficking
- From:
Acta Pharmaceutica Sinica B
2021;11(4):1047-1055
- CountryChina
- Language:English
-
Abstract:
Psoriasis is an autoimmune inflammatory disease, where dendritic cells (DCs) play an important role in its pathogenesis. In our previous work, we have demonstrated that topical delivery of curcumin-loaded poly (lactic-
