Cryptobiosis-inspired assembly of

Author: Hu ZHOU ¹ ; Gang HE ² ; Yanbin SUN ² ; Jingguo WANG ² ; Haitao WU ² ; Ping JIN ¹ ; Zhengbao ZHA ²
Author Information

1. Shenzhen Maternity and Child Healthcare Hospital, Shandong University, Shenzhen 518028, China.
2. School of Food and Biological Engineering, School of Instrument Science and Opto-Electronics Engineering, Hefei University of Technology, Hefei 230009, China.
Publication Type:Journal Article
Keywords: Cryptobiosis; Drug delivery; Polyphenol‒metal chemistry; Tumor microenvironment; “AND” logic gate
From: Acta Pharmaceutica Sinica B 2021;11(2):534-543
CountryChina
Language:English
Abstract: Developing tumor-specific drug delivery systems with minimized off-target cargo leakage remains an enduring challenge. In this study, inspired from the natural cryptobiosis explored by certain organisms and stimuli-responsive polyphenol‒metal coordination chemistry, doxorubicin (DOX)-conjugated gelatin nanoparticles with protective shells formed by complex of tannic acid and Fe