Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy.

Author: Junjing YIN ¹ ; Haiqiang CAO ² ; Hong WANG ² ; Kaoxiang SUN ¹ ; Yaping LI ¹ ; Zhiwen ZHANG ²
Author Information

1. School of Pharmacy, Yantai University, Yantai 264005, China.
2. State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Publication Type:Journal Article
Keywords: Cancer metastasis; Cancer therapy; Catalase; Drug delivery; Nanoparticle; Photodynamic therapy; Tumor hypoxia; Tumor penetration; Tumor targeting
From: Acta Pharmaceutica Sinica B 2020;10(11):2246-2257
CountryChina
Language:English
Abstract: Hypoxia is a serious impediment to current treatments of many malignant tumors. Catalase, an antioxidant enzyme, is capable of decomposing endogenous hydrogen peroxide (H