Compound Sophorae Decoction: treating ulcerative colitis by affecting multiple metabolic pathways.
10.1016/S1875-5364(21)60029-8
- Author:
Zong-Chao HONG
1
,
2
;
Quan CAI
3
;
He-Zhen WU
4
;
Yan-Fang YANG
4
;
Heng FAN
5
;
Xue-Yun DUAN
6
Author Information
1. Hubei University of Chinese Medicine, Wuhan 430065, China; Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China. Electronic address: ZCHong369@
2. com.
3. Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Huangshi No.5 Hospital, Huangshi 435005, China. Electronic address: 3234548100@qq.com.
4. Hubei University of Chinese Medicine, Wuhan 430065, China.
5. Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. Electronic address: fanheng009@aliyun.com.
6. Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China; Hubei Province Academy of Traditional Chinese Medicine, Wuhan 430074, China. Electronic address: xueyunduan@sina.com.
- Publication Type:Journal Article
- Keywords:
Biomarker;
Compound Sophorae Decoction;
LC-MS/MS;
Metabolomics;
Ulcerative colitis
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(4):267-283
- CountryChina
- Language:English
-
Abstract:
Ulcerative colitis (UC) is a chronic refractory non-specific intestinal inflammatory disease that is difficult to be cured. The discovery of new ulcerative colitis-related metabolite biomarkers may help further understand UC and facilitate early diagnosis. It may also provide a basis for explaining the mechanism of drug action in the treatment of UC. Compound Sophorae Decoction (CSD) is an empirical formula used in the clinical treatment of UC. Although it is known to be efficacious, its mechanism of action in the treatment of UC is unclear. The purpose of this study was to investigate the changes in endogenous substances in UC rats and the effects of CSD on metabolic pathways using the metabonomics approach. Metabolomics studies in rats with UC and normal rats were performed using LC-MS/MS. Rats with UC induced using TNBS enema were used as the study models. Metabolic profiling and pathway analysis of biomarkers was performed using statistical and pathway enrichment analyses. 36 screened potential biomarkers were found to be significantly different between the UC and the normal groups; it was also found that CSD could modulate the levels of these potential biomarkers. CSD was found to be efficacious in UC by regulating multiple metabolic pathways.
