Altered integrity of hepatocyte tight junctions in rats with triptolide-induced cholestasis.

Shan HUANG; Li LIU; Hui-Fang MEI; Qian-Wen ZHANG; Xi ZHANG; Xiao-Ting XU; Xin-Zhi WANG; Xin HUANG; Tao WANG; Zhen-Zhou JIANG; Lu-Yong ZHANG; Li-Xin SUN

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Altered integrity of hepatocyte tight junctions in rats with triptolide-induced cholestasis.

Author: Shan HUANG ¹ ; Li LIU ² ; Hui-Fang MEI ² ; Qian-Wen ZHANG ² ; Xi ZHANG ² ; Xiao-Ting XU ² ; Xin-Zhi WANG ² ; Xin HUANG ² ; Tao WANG ² ; Zhen-Zhou JIANG ² ; Lu-Yong ZHANG ³ ; Li-Xin SUN ^{4
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Author Information

1. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China; Changde Vocational Technology College, Changde 415000, China.
2. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China.
3. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China; Center for Drug Research and Development, Guangdong Pharmaceutical University, Guangzhou 510006, China. Electronic address: lyzhang@cpu.edu.cn.
4. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China; Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China. Electronic address: slxcpu@
5. com.
Publication Type:Journal Article
Keywords: Cholestatic injury; Sandwich-cultured primary hepatocytes; Tight junction; Triptolide
From: Chinese Journal of Natural Medicines (English Ed.) 2021;19(3):188-194
CountryChina
Language:English
Abstract: Triptolide (TP), an active component of Tripterygium wilfordiiHook. f. (TWHF), has been widely used for centuries as a traditional Chinese medicine. However, the clinical application of TP has been restricted due to multitarget toxicity, such as hepatotoxicity. In this study, 28 days of oral TP administration (100, 200, or 400 μg·kg