Ligustroflavone ameliorates CCl
10.1016/S1875-5364(21)60018-3
- Author:
Rong KANG
1
;
Wen TIAN
2
;
Wei CAO
3
;
Yang SUN
2
;
Hui-Nan ZHANG
2
;
Ying-Da FENG
2
;
Chen LI
2
;
Ze-Zhi LI
4
;
Xiao-Qiang LI
5
Author Information
1. Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Fourth Military Medical University, Xi'an 710032, China; Department of Natural Medicine and Institute of Materia Medica, Fourth Military Medical University, Xi'an 710032, China.
2. Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Fourth Military Medical University, Xi'an 710032, China.
3. Department of Natural Medicine and Institute of Materia Medica, Fourth Military Medical University, Xi'an 710032, China; Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling 712000, China.
4. Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling 712000, China.
5. Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Fourth Military Medical University, Xi'an 710032, China. Electronic address: xxqqli@fmmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
HSCs;
Ligustroflavone;
Liver fibrosis;
TGF-β/Smad
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(3):170-180
- CountryChina
- Language:English
-
Abstract:
Liver fibrosis is a pathological process characterized by excess deposition of extracellular matrix (ECM) that are mainly derived from activated hepatic stellate cells. Previous studies suggested that ligustroflavone (LF) was an ingredient of Ligustrum lucidum Ait. with activities of anti-inflammation and anti-oxidation. In this study, we investigated whether LF had any effect on liver fibrosis. In our study, we established a mouse model of carbon tetrachloride (CCl
