The effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA, salvianolic acid B and ginsenoside Rg
10.1016/S1875-5364(21)60016-X
- Author:
Jie ZHANG
1
;
Sheng-Lan LIU
2
;
Hui WANG
3
;
Li-Ying SHI
4
;
Jin-Ping LI
5
,
6
;
Lu-Juan JIA
4
;
Bao-Ping XIE
7
Author Information
1. The Third Xiangya hospital, Central South University, Changsha 410013, China.
2. The Fourth Hospital of Changsha, Changsha 410013, China.
3. The Central Hospital of Taian, Taian 271000, China.
4. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
5. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China. Electronic address: pjingli@
6. com.
7. Gannan Medical University, Gannan, 341000, China.
- Publication Type:Journal Article
- Keywords:
Borneol;
Fufang Danshen preparation;
Ginsenoside Rg1;
Pharmacokinetics;
Salvianolic acid B;
Tanshinone IIA
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(2):153-160
- CountryChina
- Language:English
-
Abstract:
Fufang Danshen preparation (FDP) is consisted of Salviae Miltiorrhizar Radix et Rhizoma (Danshen), Notoginseng Radix et Rhizoma (Sanqi) and Borneolum Syntheticum (borneol). FDP is usually used to treat myocardial ischemia hypoxia, cerebral ischemia and alzheimer's disease, etc. In the treatment of cerebrovascular diseases, borneol is usually used to promote the absorption and distribution of the bioactive components to proper organs, especially to the brain. The purpose of this study is investigating the effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA (TS IIA), salvianolic acid B (SAB) and ginsenoside Rg1 in FDP. Male healthy Sprague-Dawley (SD) rats were given Danshen extracts, Sanqi extracts (Panax notoginsengsaponins) or simultaneously administered Danshenextracts, Sanqi extracts and borneol. Plasma and brain samples were collected at different points in time. The concentration of TS IIA, SAB and Rg1 was determined by UPLC-MS/MS method. The main pharmacokinetics parameters of plasma and brain tissue were calculated by using Phoenix WinNolin 6.1 software. In comparison with Danshen and Sanqi alone, there were significant differences in pharmacokinetic parameters of TS IIA, SAB and Rg1, and the brain distribution of SAB and TS IIA when Danshen, Sanqi and borneol were administrated together. Borneol statistically significant shortened t
