Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB, NLRP3 pathway.
10.1016/S1875-5364(21)60012-2
- Author:
Li-Yan LEI
1
;
Rui-Cheng WANG
2
;
Ya-Lei PAN
1
;
Zheng-Gang YUE
1
;
Rui ZHOU
1
;
Pei XIE
1
;
Zhi-Shu TANG
3
,
4
Author Information
1. Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi University of Chinese Medicine, Xianyang 712083, China.
2. The Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China.
3. Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi University of Chinese Medicine, Xianyang 712083, China. Electronic address: zst6565@
4. com.
- Publication Type:Journal Article
- Keywords:
Inflammation;
Mangiferin;
Microglial polarization;
NF-κB;
NLRP3 inflammasome
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(2):112-119
- CountryChina
- Language:English
-
Abstract:
Inflammation plays important roles in the progress of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. Microglia is responsible for the homeostasis of the central nervous system (CNS), and involved in the neuroinflammation. Therefore, it could be potential in treatment of neurodegenerative diseases to suppress the microglia-mediated neuroinflammation. Mangiferin, a major glucoside of xanthone in Anemarrhena Rhizome, has anti-inflammatory, anti-diabetes, and anti-oxidative properties. However, the effect of mangiferin on the inflammatary responses of microglia cells are still poorly understand. In this study, we investigated the mechanism by which mangiferin inhibited inflammation in LPS-induced BV
