Pathogenesis of NASH and Promising Natural Products.
10.1016/S1875-5364(21)60002-X
- Author:
Ying-Rong LENG
1
;
Mei-Hui ZHANG
1
;
Jian-Guang LUO
2
;
Hao ZHANG
3
Author Information
1. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
2. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: luojg@cpu.edu.cn.
3. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zhanghao@cpu.edu.cn.
- Publication Type:Review
- Keywords:
Animal model;
NASH;
Natural medicine;
Pathogenesis;
Target
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(1):12-27
- CountryChina
- Language:English
-
Abstract:
Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to advanced liver diseases. The mechanism of the diaease progression, which is lacking effective therapy, remains obsure. Therefore, there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies. To accomplish this goal, experimental animal models that recapitulate the human disease are necessary. Currently, an increasing number of studies have focused on natural constituents from medicinal plants which have been emerged as a new hope for NASH. This review summarized the pathogenesis of NASH, animal models commonly used, and the promising targets for therapeutics. We also reviewed the natural constituents as potential NASH therapeutic agents.
