Genome-wide analysis of hippocampal transfer RNA-derived small RNAs identifies new potential therapeutic targets of Bushen Tiansui formula against Alzheimer's disease.
10.1016/j.joim.2020.12.005
- Author:
Zhe-Yu ZHANG
1
;
Chun-Hu ZHANG
2
;
Jing-Jing YANG
2
;
Pan-Pan XU
1
;
Peng-Ji YI
1
;
Mu-Li HU
3
;
Wei-Jun PENG
4
Author Information
1. Department of Integrated Traditional Chinese & Western Medicine, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
2. Department of Integrated Traditional Chinese & Western Medicine, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
3. Department of Scientific Research, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.
4. Department of Integrated Traditional Chinese & Western Medicine, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China. Electronic address: pengweijun87@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease;
Endocannabinoids;
Hippocampus;
Small non-coding RNAs;
Traditional Chinese medicine;
Transfer RNA
- From:
Journal of Integrative Medicine
2021;19(2):135-143
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:Bushen Tiansui formula (BSTSF), a traditional Chinese medicine prescription, has been widely used to treat Alzheimer's disease (AD). However, the mechanisms underlying its effects remain largely unknown. In this study, a rat AD model was used to study the effects of BSTSF on cognitive performance and expression of transfer RNA-derived small RNAs (tsRNAs) in the hippocampus, to determine whether treatment of AD with BSTSF could regulate the expression of tsRNAs, a novel small non-coding RNA.
METHODS:To generate a validated AD model, oligomeric amyloid-β
RESULTS:The learning and memory deficits of Aβ
CONCLUSION:This study identified a previously uncharacterized mechanism underlying the effects of BSTSF in alleviating the learning and memory deficits in Aβ
