Therapeutic effects of herbal formula Huangqisan on metabolic disorders via SREBF1, SCD1 and AMPK signaling pathway.
10.1016/j.joim.2020.11.002
- Author:
Ya-Lei LIU
1
;
Zhen-Yu ZHOU
1
;
Min GAO
2
;
Guang JI
3
;
Cheng HUANG
1
;
Sheng-Jie FAN
4
Author Information
1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
2. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; College of Pharmacy, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
3. Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
4. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: shengjiefan@shutcm.edu.cn.
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Diabetes;
Hyperlipidemia;
Obesity;
Tradition Chinese medicine
- From:
Journal of Integrative Medicine
2021;19(2):167-176
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:Metabolic syndrome is a complex medical condition that has become an alarming epidemic, but an effective therapy for this disease is still lacking. The use of the herbal formula Huangqisan (HQS) to treat diabetes is documented in the Chinese medical literature as early as 1117 A.D.; however, its therapeutic effects and underlying mechanisms remain elusive.
METHODS:To investigate the beneficial effects of HQS on metabolic disorders, high-fat diet-induced obesity (DIO), leptin receptor dysfunction (db/db) and low-density lipoprotein receptor-knockout (LDLR
RESULTS:HQS lowered body weight, fasting blood glucose and serum lipid levels and improved glucose tolerance and insulin sensitivity in DIO mice and db/db mice (P < 0.05). HQS also blocked atherosclerotic plaque formation in LDLR
CONCLUSION:HQS is effective for reversing metabolic disorder and has the potential to be used as therapy for metabolic syndrome.
