Electroacupuncture protects septic rats from acute lung injury through the JAK1/STAT3 pathway.
10.12122/j.issn.1673-4254.2020.11.20
- Author:
Cancan XIE
1
;
Shuanghua WU
1
;
Zhengrong LI
1
;
Bing HUANG
1
;
Weizhong ZENG
1
Author Information
1. Department of Critical Medicine, Zhuzhou Central Hospital, Zhuzhou 412000, China.
- Publication Type:Journal Article
- Keywords:
JAK1/STAT3 pathway;
acute lung injury;
electroacupuncture;
sepsis
- MeSH:
Acute Lung Injury/therapy*;
Animals;
Electroacupuncture;
Lung;
Male;
Rats;
Rats, Sprague-Dawley;
Sepsis/therapy*;
Tumor Necrosis Factor-alpha
- From:
Journal of Southern Medical University
2020;40(11):1662-1667
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the protective effect of electroacupuncture against acute lung injury (ALI) in septic rats and explore the mechanism.
METHODS:Sixty male SD rats were randomly divided into cecal ligation and puncture (CLP)-induced sepsis group (
RESULTS:Compared with those in the sham operation group, the rats in ALI group showed obvious lung pathologies with significantly increased lung W/D ratio (
CONCLUSIONS:Electroacupuncture can inhibit the release of inflammatory mediators and cell apoptosis via the JAK1/STAT3 pathway to reduce lung injuries in septic rats.
