Chronic myeloid leukemia with a significant increase of monocytes and rare karyotype: A case report and literature review.
10.11817/j.issn.1672-7347.2021.200273
- Author:
Ying ZHANG
1
,
2
,
3
;
Qian TAN
1
;
Pengfei CAO
1
;
Cong CHEN
1
;
Wei CHEN
3
,
4
Author Information
1. Department of Hematology, Xiangya Hospital, Central South University, Changsha
2. hncsxyxyk@
3. com.
4. Department of Gastroenterology, Changsha Central Hospital, Changsha 410004, China. chenwei1613@
- Publication Type:Review
- Keywords:
7) (p13;
chromosome translocation t(2;
chronic myeloid leukemia;
chronic myelomonocytic leukemia;
p22)
- MeSH:
Adult;
Humans;
Karyotype;
Karyotyping;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics*;
Male;
Monocytes;
Translocation, Genetic
- From:
Journal of Central South University(Medical Sciences)
2021;46(3):322-327
- CountryChina
- Language:English
-
Abstract:
Chronic myeloid leukemia with a significant increase of monocytes is rare and difficult to identify from chronic myelo-monocytic leukemia in clinic. A 31-year-old male patient with systemic pain was initially diagnosed as chronic myelo-monocytic leukemia, who was finally diagnosed as chronic myeloid leukemia by fusion gene and chromosome examination. In addition to the typical Ph chromosome, a rare chromosome translocation t(2; 7)(p13; p22) was observed. The detection of monocyte subsets by multi-parameter flow cytometry is a diagnostic marker to distinguish the above 2 diseases. The relationship between fusion genes and mononucleosis is not clear. Tyrosine kinase inhibitors or allogeneic hematopoietic stem cell transplantation can be used in the treatment for this disease.
