Epstein
10.11817/j.issn.1672-7347.2021.190744
- Author:
Weiming LI
1
,
2
;
Weihong YI
1
;
Dazhi YANG
1
;
Guiyuan LI
3
Author Information
1. Department of Orthopedics, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Guangdong
2. liweiming@csu.edu.cn.
3. Institute of Cancer Research, Central South University, Changsha 410078, China. lgy@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Epstein-Barr virus-encoded microRNAs;
epithelial-mesenchymal transition;
latent infection;
tumor
- MeSH:
Carcinogenesis/genetics*;
Epstein-Barr Virus Infections/genetics*;
Gene Expression Regulation, Neoplastic;
Herpesvirus 4, Human/genetics*;
Humans;
MicroRNAs/genetics*;
Nasopharyngeal Neoplasms/genetics*
- From:
Journal of Central South University(Medical Sciences)
2021;46(3):300-308
- CountryChina
- Language:English
-
Abstract:
Epstein-Barr virus (EBV), a definite tumorigenic virus, is closely related to the development of nasopharyngeal cancer, gastric cancer, lymphoma and other tumors. EBV encodes a total of 44 mature microRNAs, which can regulate the expression of virus and host genes. EBV-encoded microRNAs and their regulated target molecules participate in the biological functions of tumor apoptosis, proliferation, invasion, and metastasis during tumorigenesis and development, and play an important role in the development of tumor.
