Research progress in nervous system damage caused by SARS
10.11817/j.issn.1672-7347.2020.200429
- Author:
Peng HUANG
1
,
2
;
Li TANG
1
;
Yi REN
1
;
Liqun LIU
1
,
3
Author Information
1. Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha
2. 188212179@csu.edu.cn.
3. liuliqun@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
coronavirus disease 2019;
nervous system;
severe acute respiratory syndrome coronavirus 2
- MeSH:
Betacoronavirus;
COVID-19;
Coronavirus Infections/epidemiology*;
Humans;
Pandemics;
Peptidyl-Dipeptidase A;
Pneumonia, Viral/epidemiology*;
Research;
SARS-CoV-2
- From:
Journal of Central South University(Medical Sciences)
2020;45(10):1247-1254
- CountryChina
- Language:English
-
Abstract:
The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major outbreak in the world. SARS-CoV-2 infection can not only involve in the respiratory system, but also cause severe nervous system damage. Studies have shown that SRAS-CoV-2 can invade the nervous system through hematogenous and transneuronal pathways, and may cause nervous system damage in patients with COVID-19 by inhibiting cellular immunity, hypoxemia, inflammation, inducing neuronal degeneration and apoptosis, and angiotensin converting enzyme 2 (ACE2) mechanism. It can lead to intracranial infection, toxic encephalopathy, acute cerebrovascular disease, muscle damage, peripheral nervous system injury, acute myelitis, demyelination disease or other nervous system diseases.
