Effect of Danhong Injection () on Improving Coronary Microcirculation Injury after Percutaneous Coronary Intervention.
10.1007/s11655-021-2853-4
- Author:
Qing-Rong LIU
1
;
Hong-Xu LIU
2
;
Wen-Long XING
2
;
Qi ZHOU
2
;
Hong-Liang ZHANG
1
;
Hai-Tong ZHANG
1
;
Guang-Yuan SONG
1
;
Yong-Jian WU
3
,
4
Author Information
1. Department of Cardiology, Fuwai Hospital of Chinese Academy of Medical Sciences, Beijing, 100037, China.
2. Department of Cardiology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, 100010, China.
3. Department of Cardiology, Fuwai Hospital of Chinese Academy of Medical Sciences, Beijing, 100037, China. yongjianwu_nccd@
4. com.
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
Danhong Injection;
coronary artery;
coronary microcirculation injury;
interventional therapy
- From:
Chinese journal of integrative medicine
2021;27(6):455-460
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To explore the effectiveness of Danhong Injection () on improving microcirculatory injury after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD).
METHODS:A randomized controlled trial was conducted and 90 patients were enrolled. A random sequence was generated using statistical analysis software. Patients with microcirculatory injuries after PCI were randomly divided into 3 groups for treatment (30 subjects in each group): Danhong Injection group: after PCI, Danghong Injections were given with intravenous administration with 40 mL twice a day for a week; statins intensive group: after PCI, atorvastatin calcium tablets were given oral medication with 80 mg once, and then atorvastatin 40 mg daily for 1 week; the control group: after PCI, atorvastatin calcium tablets were given oral medication with 10-20 mg daily for 1 week. The index of microcirculation resistance (IMR) was used to assess microcirculatory injury during PCI. The IMR of the target vessel was reexamined after 1 week of drug treatment.
RESULTS:After one week's drug treatment, IMR was significantly decreased in both statins intensive group and Danhong Injection group compared with the control group (P<0.01), but no difference was found between statins intensive group and Danhong injection group (14.03 ± 2.54 vs. 16.03 ± 5.72 U, P=0.080).
CONCLUSIONS:The efficacy of Danhong Injection is non-inferior to statin. Early use of Danhong Injection after PCI can effectively improve coronary microcirculation injury after PCI.
