Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16
10.1007/s11655-020-3098-3
- Author:
Jue WANG
1
;
Yin-Yin YING
1
;
Zhao-Hui CHEN
2
;
Ke-Ding SHAO
3
;
Wei-Ping ZHANG
1
;
Sheng-You LIN
4
,
5
Author Information
1. Department of Oncology, the Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, China.
2. Department of Oncology, Ningbo Forth Hospital, Ningbo, Zhejiang Province, 315700, China.
3. Science Research Department, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
4. Department of Oncology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, 310007, China. linsy0628@
5. com.
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
Guilu Erxian Glue;
bone marrow suppression;
hematopoietic stem cell senescence;
p16INK4a
- From:
Chinese journal of integrative medicine
2020;26(11):819-824
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To evaluate the effect of Guilu Erxian Glue (, GEG) on cyclophosphamide (CTX)-induced bone marrow hematopoietic stem cells (HSCs) senescence in mice and explore the underlying mechanism.
METHODS:The H
RESULTS:Compared with the model group, GEG increased cell viability as well as proliferation (P<0.05 or P<0.01) and reduced β -gal expression. Furthermore, GEG significantly decreased the expressions of p16
CONCLUSION:GEG can alleviate CTX-induced HSCs senescence in mice, and the p16
